Intra-articular injections of bone morphogenetic protein-7 retard progression of existing cartilage degeneration
نویسندگان
چکیده
منابع مشابه
Weekly intra-articular injections of bone morphogenetic protein-7 inhibits osteoarthritis progression
INTRODUCTION We investigated the ability of a weekly intra-articular injection of bone morphogenetic protein (BMP)-7 to prevent osteoarthritis in rabbits with anterior cruciate ligament transections. METHODS First, 36 knee joints were randomly divided into four groups: 50, 500, 5,000 ng BMP-7, and control. Knee cartilage was evaluated at 4, 8, and 12 weeks. Then, in order to control for indiv...
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An attempt was made to ascertain whether intra-articular corticosteroids exert a harmful effect on primate cartilage. The knee joints of 10 Macaca irus monkeys were subjected to either one, two, or six injections of 20 mg methyl prednisolone or an equal number of control injections over a 12-week period. Minor degenerative changes of many femoral condyles were shown by India ink staining and by...
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The purpose of this study was to investigate the role of bone morphogenetic proteins (BMPs), such as BMP-7, growth factors, and cytokines, in the accumulation of superficial zone protein (SZP) in bovine articular cartilage. Calf superficial articular cartilage discs and chondrocytes were obtained for explant and monolayer culture systems, respectively. Dose- and time-dependent actions of BMP-7 ...
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Background: Autologous periosteal grafting is used as treatment for articular cartilage defect. Objective: To study the effect of bone morphogenetic protein (BMP) on articular cartilage regeneration following periosteal grafting. Methods: 16 healthy 15-week-old New Zealand white rabbits of both sexes (32 knees) were randomly divided into experimental group (group A) and control group (group B)....
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INTRODUCTION Recent studies have revealed that rapamycin activates autophagy in human chondrocytes preventing the development of osteoarthritis (OA) like changes in vitro, while the systemic injection of rapamycin reduces the severity of experimental osteoarthritis in a murine model of OA in vivo. Since the systemic use of rapamycin is associated with numerous side effects, the goal of the curr...
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ژورنال
عنوان ژورنال: Journal of Orthopaedic Research
سال: 2010
ISSN: 0736-0266
DOI: 10.1002/jor.21165